The nine-day voyage sails Aug. 22 and includes a pre-cruise hotel stay in St. Louis.
The Mississippi River played a major influence in Twain's work, from his days as a riverboat pilot to stories like 'The Adventures of Tom Sawyer.'
On-board presentations by Cindy Lovell, executive director of the Mark Twain House and Museum in Hartford, Connecticut, and Henry Sweets, executive director of Mark Twain Boyhood Home & Museum, Hannibal, include 'Life on the Mississippi,' an interactive session including highlights of Twain's time on the river, a reading from the book and a 'lightning round' of Mississippi River Jeopardy.
'Mark Twain Today: His Relevance and Reach,' will discuss what recently made Smithsonian magazine dub Mark Twain as the No. 1 influence in pop culture. Other presentations will delve into Hannibal's history, events from Twain's childhood that made it into 'The Adventures of Tom Sawyer' and a question and answer session with Lovell, Sweets and Hankins.
A tour of Hannibal on the 'Twainland Express' is included, and American Queen's ensemble cast will present a musical matinee on board evoking 'Life on the Mississippi.'