The 114,500gt Costa Favolosa sails in on Saturday, while the 92,400gt MSC Orchestra is due on Sunday.
Both ships will be offering weekly departures from Pointe-à-Pitre for the season.
On Saturdays and Sundays multilingual representatives of the Guadeloupe Islands Tourism Board will be present at the port to welcome their passengers.
The 2015/16 season is the 21st that Costa Cruises has embarked travelers in Guadeloupe. MSC Cruises began doing so in the 2012/13 season.