Spain, Portugal and the Canary Islands itineraries, featuring calls at Lisbon and Bilbao, will take place on board Ventura.
Departing and returning to Southampton, new ship Iona will sail seven-night Norwegian fjords cruises calling at Stavanger, Olden, Ålesund and Haugesund, and Aurora will sail the Arctic Circle with an overnight stay in Reykjavik plus North Cape scenic cruising.
Britannia will sail the Mediterranean, calling at La Spezia for Florence and Pisa, with an overnight stay at Barcelona. The vessel will also offer Baltic sailings, including two-day calls to St Petersburg and visits to Helsinki and Tallinn.
Azura will embark on fly-cruises from Malta with itineraries including Trieste, for visits to Venice, and Kusadasi for the ruins of Ephesus. The ship will also sail to Taranto in southern Italy.
Four-night breaks to Amsterdam, as well as a 30-night itinerary to North America and Canada will also be available.
'All our summer 2022 holidays are available with a 5% low deposit ... and the opportunity to spread the cost monthly at no additional cost,' said Paul Ludlow, president, P&O Cruises.
'Additionally, our flexible booking conditions allow guests to move their booking as many times as they like before paying their holiday balance.’
Pre-registration starts today and offers are available until December 14.